Should mylanta and ranitidine be taken together
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Can You Take A H2 Blocker With A PPI (Proton Pump Inhibitor)?
Feb 04, 2018
Jwork asked
Can you take H2 blockers with PPIs (proton pump inhibitors?
I just started taking Protonix (pantoprazole) today 40 mg twice a day.
Zantac
I am starting get indigestion. Can I take Pepcid AC (famotidine) with it?
Answer
There a minor drug interaction between H2 blockers and PPIs (proton pump inhibitors), but only in terms of their conflicting mechanisms of action.
Due to how these medications work, using them at the same time could make them less effective (which is discussed below). However, using both together won't increase the risk of adverse effects.
There are certain situations where the combination of the two medications may provide extra benefit, but they need to be administered at appropriate times.
We discuss this and more below.
PPI Use With H2 Blockers
H2 Blockers and PPIs are two distinct classes of medication that are used the treat excess stomach acid. Excess stomach acid is associated with a variety of conditions including heartburn, esophageal reflex disease (i.e
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